Beilstein J. Org. Chem.2022,18, 1544–1552, doi:10.3762/bjoc.18.164
UHPLC–MS analysis of the extract from this sponge indicated the presence of a new alkaloid. Large-scale extraction and mass-directed isolation studies on the CH2Cl2/MeOH I. basta extract resulted in the purification of a new bromotyrosine-derived alkaloid, 5-debromopurealidinH (1), along with the known
(6), hexadellin A (9) and bastadin 4 (5) showed inhibition towards larval motility after 72 h of exposure with IC50 values of 1.6 µM, 10.0 µM and 33.3 µM, respectively.
Keywords: alkaloid; anthelmintic; biodiscovery; bromotyrosine; 5-debromopurealidinH; Ianthella; NatureBank; sponge; Introduction
large-scale extraction, mass-directed isolation and structure elucidation of a new bromotyrosine-derived alkaloid to which we have given the trivial name 5-debromopurealidinH (1). The anthelmintic evaluation of this new compound, along with seven previously reported and related marine bromotyrosines
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Graphical Abstract
Figure 1:
UHPLC–UV chromatogram (254 nm) of the CH2Cl2/MeOH extract of Ianthella basta (NB6021519); retention...